Salivary heat shock proteins and their interactions with oral microenvironment
نویسندگان
چکیده
Salivary proteomics is an intriguing area of immunobiological interactions. Heat shock proteins are uniquely conserved molecules that maintain high percentage of homology in all species. These proteins mainly act by inducing antiapoptotic and immunoregulatory mechanisms in intraas well as extracellular milieu. They have been proposed to play an important role in saliva by maintenance of microbiological population. Their contributory protective role in cancer biology is an interesting area of research having immense implications in therapeutics.
منابع مشابه
Evaluation of Salivary Level of Heat Shock Protein 70 in Patients with Breast Cancer
Introduction: Breast cancer is the most common cancer diagnosed among women worldwide. Increased molecular and genetic information about cancer has improved diagnostic, screening, and treatment methods for cancer. Heat shock protein 70 (HSP70) is overexpressed in breast cancer patients and involved in malignant properties of breast cancer. Due to the noninvasive nature of saliva collection and ...
متن کاملSalivary Defense Proteins: Their Network and Role in Innate and Acquired Oral Immunity
There are numerous defense proteins present in the saliva. Although some of these molecules are present in rather low concentrations, their effects are additive and/or synergistic, resulting in an efficient molecular defense network of the oral cavity. Moreover, local concentrations of these proteins near the mucosal surfaces (mucosal transudate), periodontal sulcus (gingival crevicular fluid) ...
متن کاملSaliva as a biomarker of heat shock protein 70 in poor oral health
Background: The Heat shock proteins are stress induced and there is increased evidence of presence of these chaperons extracellular which is considered to be intracellular. Their present cytokine like effect and help in immune recognition, thus indicate strong extracellular action of heat shock protein 70 in maintaining integrity of oral cavity. Hypothesis: The aim of this study was to evaluate...
متن کاملPhosphoglycerate kinase and fructose bisphosphate aldolase of Candida albicans as new antigens recognized by human salivary IgA.
BACKGROUND Candida albicans is an opportunistic dimorphic fungus commonly present in the human oral cavity that causes infections in immunocompromised patients. The antigen variability, influenced by growth conditions, is a pathogenicity factor. AIMS To determine the effect of nutritional and heat stress on the antigen expression of C. albicans, and to identify major antigens recognized by hu...
متن کاملCell phone use and parotid salivary gland alterations: no molecular evidence.
BACKGROUND The association between cell phone use and the development of parotid tumors is controversial. Because there is unequivocal evidence that the microenvironment is important for tumor formation, we investigated in the parotid glands whether cell phone use alters the expression of gene products related to cellular stress. METHODS We used the saliva produced by the parotid glands of 62...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015